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Ventilatory control in infants, children, and adults with bronchopulmonary dysplasia

Melissa L Bates1, De-Ann M Pillers, Mari Palta

  • 1Department of Pediatrics, Division of Critical Care, University of Wisconsin, Madison, WI, USA; John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, WI, USA.

Respiratory Physiology & Neurobiology
|July 27, 2013
PubMed

Insights

Bronchopulmonary dysplasia (BPD) involves altered breathing control in preterm infants. This impacts respiratory function during exercise, sleep, hypoxia, and lung disease, requiring further research.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Respiratory Physiology

Background:

  • Bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity, affects approximately 30% of preterm infants annually.
  • BPD is linked to mechanical ventilation and/or high oxygen exposure at birth.
  • Altered ventilatory control is a key characteristic of BPD.

Purpose of the Study:

  • To describe changes in ventilatory control in patients with BPD.
  • To examine ventilatory control under metabolic stressors like exercise, sleep, hypoxia, and lung disease.
  • To identify future research directions in BPD and ventilatory control.

Main Methods:

  • Focused on human infant, child, and adult studies.
  • Analyzed alterations in chemoreceptor function, respiratory muscle function, and suprapontine control.
  • Contextualized findings within metabolic stressors challenging O2 supply and CO2 elimination.

Main Results:

  • Patients with BPD exhibit altered chemoreceptor and respiratory muscle function.
  • Suprapontine control mechanisms are also affected in BPD.
  • Ventilatory control dysfunctions are evident under physiological stress.

Conclusions:

  • Ventilatory control deficits are a significant aspect of BPD.
  • Understanding these deficits under stress is crucial for managing BPD.
  • Longitudinal studies with defined cohorts are recommended for future research.

Keywords:
Bronchopulmonary dysplasiaExerciseHypoxiaPremature infantSleepVentilatory control

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