Related Experiment Video
Updated: May 9, 2026
08:55
Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
Published on: August 7, 2018
A novel necroptosis inhibitor-necrostatin-21 and its SAR study
1State Key Laboratory of Bio-organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Bioorganic & Medicinal Chemistry Letters
|July 27, 2013
Abstract:
An initial structure-activity relationship study of the novel necroptosis inhibitor Nec-21 was described. Any changes of the tetracyclic scaffold were detrimental for the activity. Introduction of a substituent to 7 or 8 position (e.g., cyano or methoxy group, respectively), would increase the activity. The 7 and 8-position disubstituted compound 17 b was 35-fold as potent as the lead, while EC50 reached 14 nM.
