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Assessment of angiographic vascularity of meningiomas with dynamic susceptibility contrast-enhanced
1From the Departments of Medical Imaging and Intervention (C.H.T, Y.-W.P., S.-H.N, H.-F.W.).
Background And Purpose:
The roles of DTI and dynamic susceptibility contrast-enhanced-PWI in predicting the angiographic vascularity of meningiomas have not been studied. We aimed to investigate if these 2 techniques could reflect the angiographic vascularity of meningiomas.
Materials And Methods:
Thirty-two consecutive patients with meningiomas who had preoperative dynamic susceptibility contrast-enhanced-PWI, DTI, and conventional angiography were retrospectively included. The correlations between angiographic vascularity of meningiomas, classified with a 4-point grading scale, and the clinical or imaging variables-age and sex of patient, as well as size, CBV, fractional anisotropy, and ADC of meningiomas-were analyzed. The meningiomas were dichotomized into high-vascularity and low-vascularity groups. The differences in clinical and imaging variables between the 2 groups were compared. Receiver operating characteristic curve analysis was used to determine the diagnostic performance of these variables.
Results:
In meningiomas, angiographic vascularity correlated positively with CBV but negatively with fractional anisotropy. High-vascularity meningiomas demonstrated significantly higher CBV but lower fractional anisotropy as compared with low-vascularity meningiomas. In differentiating between the 2 groups, the area under the curve values were 0.991 for CBV and 0.934 for fractional anisotropy on receiver operating characteristic curve analysis.
Conclusions:
CBV and fractional anisotropy correlate well with angiographic vascularity of meningiomas. They may differentiate between low-vascularity and high-vascularity meningiomas.
Insights
Diffusion tensor imaging (DTI) and dynamic susceptibility contrast-enhanced-perfusion-weighted imaging (PWI) can predict meningioma vascularity. Cerebral blood volume (CBV) and fractional anisotropy (FA) effectively differentiate high- from low-vascularity tumors.
Area of Science:
- Neuroradiology
- Neuro-oncology
- Medical imaging
Background:
- The predictive role of diffusion tensor imaging (DTI) and dynamic susceptibility contrast-enhanced-perfusion-weighted imaging (PWI) for meningioma angiographic vascularity remains uninvestigated.
- Meningiomas are the most common primary intracranial tumors, and their vascularity influences treatment decisions.
Purpose of the Study:
- To assess the ability of DTI and DSC-PWI to reflect the angiographic vascularity of meningiomas.
- To determine if these imaging techniques can differentiate between high- and low-vascularity meningiomas.
Main Methods:
- Retrospective analysis of 32 meningioma patients with preoperative DSC-PWI, DTI, and conventional angiography.
- Correlation analysis between angiographic vascularity (4-point scale) and imaging parameters: cerebral blood volume (CBV), fractional anisotropy (FA), and apparent diffusion coefficient (ADC).
- Receiver operating characteristic (ROC) curve analysis to evaluate diagnostic performance.
Main Results:
- Angiographic vascularity showed a positive correlation with CBV and a negative correlation with FA.
- High-vascularity meningiomas exhibited significantly higher CBV and lower FA compared to low-vascularity ones.
- ROC analysis yielded high diagnostic performance: AUC of 0.991 for CBV and 0.934 for FA in differentiating tumor vascularity.
Conclusions:
- CBV and FA derived from DSC-PWI and DTI, respectively, are reliable indicators of meningioma angiographic vascularity.
- These parameters effectively distinguish between high- and low-vascularity meningiomas, aiding in preoperative assessment.
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