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Related Experiment Video

Updated: May 9, 2026

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
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A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Neurodevelopment after fetal growth restriction.

Ahmet A Baschat1

  • 1Center for Advanced Fetal Care, Department of Obstetrics and Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Md., USA.

Fetal Diagnosis and Therapy
|July 27, 2013
PubMed
Summary

Fetal growth restriction (FGR) complicates placental function, increasing neurodevelopmental delay risks. Prenatal tests are needed to accurately predict FGR

Area of Science:

  • Obstetrics and Gynecology
  • Fetal Medicine
  • Neonatology

Background:

  • Fetal growth restriction (FGR) is linked to placental dysfunction and neurodevelopmental delays.
  • Early-onset FGR presents with high umbilical artery (UA) Doppler resistance, leading to cardiovascular decline and preterm birth.
  • Late-onset FGR shows minimal UA Doppler changes but isolated cerebral Doppler abnormalities, risking stillbirth.

Purpose of the Study:

  • To review the neurodevelopmental risks associated with different FGR phenotypes.
  • To highlight the predictive value of head growth lag for developmental delay.
  • To assess the current limitations in prenatal risk stratification for adverse neurodevelopment in FGR.

Main Methods:

  • Literature review of studies on FGR, placental dysfunction, and neurodevelopmental outcomes.

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Neurodevelopmental Reflex Testing in Neonatal Rat Pups
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Last Updated: May 9, 2026

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A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
14:19

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

Neurodevelopmental Reflex Testing in Neonatal Rat Pups
09:35

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

Published on: April 24, 2017

  • Analysis of Doppler ultrasound findings (UA and cerebral) in relation to FGR onset and severity.
  • Correlation of cardiovascular deterioration, prematurity, and intracranial hemorrhage with neurodevelopmental sequelae.

    • Main Results:

    • Nutritional deficiency, indicated by lagging head growth, is the strongest predictor of developmental delay in FGR.
    • Severe blood flow resistance, cardiovascular decline, prematurity, and intracranial hemorrhage elevate risks for psychomotor delay and cerebral palsy.
    • In late-onset FGR, regional cerebral blood flow redistribution correlates with abnormal behavioral patterns.

    Conclusions:

    • FGR poses significant risks for neurodevelopmental delay, varying by phenotype.
    • Current prenatal diagnostic tools lack precision in stratifying neurodevelopmental risks for FGR.
    • Further research is required to develop reliable prenatal tests for predicting adverse neurodevelopmental outcomes in FGR.