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Published on: October 12, 2012

[Thromboprophylaxis in medical patients: Which modifications with the new oral anticoagulants?]

Laurent Bertoletti1, Jean-Christophe Lega, Sandrine Accassat

  • 1Université Saint-Étienne Jean-Monnet, groupe de recherche sur la thrombose (EA3065), 42023 Saint-Étienne, France; Inserm, CIE3, 42055 Saint-Étienne, France; CHU de Saint-Étienne, hôpital Nord, service de médecine et thérapeutique, avenue Albert-Raimond, 42055 Saint-Étienne, France.

Presse Medicale (Paris, France : 1983)
|July 27, 2013
PubMed

Thromboprophylaxis with low molecular weight heparin or fondaparinux is associated with a 50% reduction in the risk of venous thrombo-embolism (VTE) in medical patients. Thromboprophylaxis is indicated in the prevention of VTE in medical patients at risk of VTE. Extended thromboprophylaxis with apixaban is associated with a greater reduction in VTE events but also with an increase in bleeding events when compared to standard therapy with enoxaparine. Extended thromboprophylaxis with rivaroxaban is associated with a greater reduction in VTE events but also with an increase in bleeding events, when compared to standard therapy with enoxaparine. Rivaroxaban and apixaban are currently not indicated in medical prophylaxis.

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