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Updated: May 9, 2026

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)
Published on: May 16, 2012
Atypical adenomatous hyperplasia of prostate lacks TMPRSS2-ERG gene fusion
Liang Cheng1, Darrell D Davidson, Gregory T Maclennan
1Departments of *Pathology †Urology, Indiana University School of Medicine, Indianapolis, IN ‡Department of Pathology, Case Western Reserve University, Cleveland, OH §Department of Pathology, Cordoba University, Cordoba, Spain ∥Department of Pathological Anatomy and Histopathology, School of Medicine, Polytechnic University of the Marche Region (Ancona), Ancona, Italy ¶Department of Pathology, Singapore General Hospital, Singapore.
Abstract:
Atypical adenomatous hyperplasia (AAH) is a distinct entity in prostate pathology, defined as a well-circumscribed lobule of closely packed crowded small glands or acini. Although it has been proposed as a precursor lesion to prostate cancer, the biological nature of AAH is currently uncertain. The TMPRSS2-ERG fusion gene is a common recurrent chromosomal rearrangement in prostate cancer and in its precursor lesion, prostatic intraepithelial neoplasia. The prevalence of TMPRSS2-ERG alteration in AAH is unknown. Fifty-five separate prostate specimens containing AAH were investigated by fluorescence in situ hybridization and immunohistochemistry for TMPRSS2-ERG rearrangement. TMPRSS2-ERG rearrangements were not identified in AAH either by fluorescence in situ hybridization or by immunohistochemistry.
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