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Updated: May 9, 2026

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue
Published on: June 14, 2020
[Immunomorphological features of chronic tonsillitis]
Abstract:
The objective of the present work was to overview current concepts of immunology and pathological morphology of chronic tonsillitis. Morphological aspects of embryological development of palatine tonsils are discussed in conjunction with their participation in the formation of the immune response. Morphological and immunological peculiarities of the pathological process in chronic tonsillitis are described. It is concluded that otorhinolaryngologists must in due time identify indications for radical surgical sanitation of the pockets of chronic infection by means of bilateral tonsillectomy.
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Three primary contributing factors have been identified.
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
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Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
