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Related Concept Videos

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Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Updated: May 9, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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Published on: June 6, 2025

Relapsing polychondritis: a review.

Aman Sharma1, Karthik Gnanapandithan, Kusum Sharma

  • 1Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India, amansharma74@yahoo.com.

Clinical Rheumatology
|July 27, 2013
PubMed
Summary
This summary is machine-generated.

Relapsing polychondritis is a rare multisystem disease affecting cartilage. A new validated disease activity index may aid clinical decisions and research for this condition.

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Last Updated: May 9, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Area of Science:

  • Rheumatology
  • Immunology
  • Genetics

Background:

  • Relapsing polychondritis (RP) is a rare multisystemic autoimmune disorder.
  • It primarily affects cartilaginous and proteoglycan-rich tissues, leading to diverse clinical manifestations.
  • RP can range from cosmetic issues like auricular chondritis to life-threatening airway collapse.

Purpose of the Study:

  • To review the current literature on relapsing polychondritis.
  • To highlight the disease's rarity and variable presentation.
  • To discuss the significance of the validated Relapsing Polychondritis Disease Activity Index.

Main Methods:

  • Comprehensive literature search of scientific databases.
  • Review of studies focusing on clinical presentation, pathogenesis, and management of RP.
  • Analysis of the validation and utility of the Relapsing Polychondritis Disease Activity Index.

Main Results:

  • Relapsing polychondritis presents with a wide spectrum of symptoms, often involving cartilage in the ears and nose.
  • Severe cases can lead to organ damage and potentially fatal complications such as airway compromise.
  • Lack of awareness contributes to diagnostic challenges.
  • The validated Relapsing Polychondritis Disease Activity Index offers a tool for assessing disease activity and guiding treatment.

Conclusions:

  • Relapsing polychondritis requires increased clinical awareness due to its rarity and potential severity.
  • The validated Relapsing Polychondritis Disease Activity Index is a valuable tool for research and clinical practice.
  • Further research is needed to improve understanding and management of this complex disease.