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Updated: Jan 26, 2026

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
Published on: June 4, 2020
Optical imaging of acute epileptic networks in mice
Edgar Guevara1, Philippe Pouliot, Dang Khoa Nguyen
1École Polytechnique de Montréal, Department of Electrical Engineering, C.P. 6079 succ. Centre-ville, Montréal, Quebec H3C 3A7, Canada.
Abstract:
The potential of intrinsic optical imaging and resting-state analysis under anesthetized conditions as a tool to study brain networks associated with epileptic seizures is investigated. Using an acute model of epileptiform activity, the 4-aminopyridine model in live mice, we observe the changes in resting-state networks with the onset of seizure activity and in conditions of spiking activity. Resting-state networks identified before and after the onset of epileptiform activity show both decreased and increased homologous correlations, with a small dependence on seizure intensity. The observed changes are not uniform across the different hemodynamic measures, suggesting a potential decoupling between blood flow and metabolism in the low-frequency networks. This study supports the need for a more extensive investigation of epileptic networks including more than one independent hemodynamic measurement.
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