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Updated: May 9, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Published on: March 3, 2023
Challenge exposure to isocyanates induces changes in nasal patency in patients reporting work-related respiratory
Roberto Castano1, Victor J Johnson, Andre Cartier
1Division of Otolaryngology-Head and Neck Surgery, University of Montreal, Montréal, Quebec, Canada. roberto.castano@umontreal.ca
Objective:
To examine the utility of specific inhalation challenge (SIC) in assessing the nasal congestive response to isocyanate exposure.
Methods:
Nine patients complaining of work-related respiratory symptoms underwent SIC with exposure to isocyanate for 4 and 120 minutes on different days. Nasal volume was monitored by acoustic rhinometry and nasal congestion by the visual analogue scale (VAS) for up to 6 hours.
Results:
The 4-minute isocyanate SIC induced a nonsignificant fall in nasal volume and no increase in the VAS score. The 120-minute isocyanate SIC induced a significant fall in nasal volume at 15, 30, and 60 minutes postchallenge that was associated with a significant increase in the VAS score at 15 and 30 minutes postchallenge.
Conclusions:
SIC appears useful to assess changes in nasal patency after exposure to isocyanate. Exposure to isocyanates can induce nasal congestion that can be objectively monitored during SIC.
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