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Published on: February 27, 2018
Risk of dementia after anaesthesia and surgery
Pin-Liang Chen1, Chih-Wen Yang, Yi-Kuan Tseng
1Pin-Liang Chen, MS, Department of Computer Science and Information Engineering, National Taiwan University, Taipei; Chih-Wen Yang, MD, Department of Neurology, Taipei Veterans General Hospital, Su-Ao and Yuanshan Branch, and National Yang-Ming University School of Medicine, Taipei; Yi-Kuan Tseng, PhD, Graduate Institute of Statistics, National Central University, Jhongli; Wei-Zen Sun, MD, PhD, Department of Anaesthesiology, National Taiwan University Hospital, Taipei, Taiwan; Jane-Ling Wang, PhD, Department of Statistics, University of California, Davis, California, USA; Shuu-Jiun Wang, MD, National Yang-Ming University School of Medicine, and Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei; Yen-Jen Oyang, PhD, Department of Computer Science and Information Engineering, National Taiwan University, and Graduate Institutes of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei; Jong-Ling Fuh, MD, Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, and National Yang-Ming University School of Medicine, Taipei, Taiwan.
Background:
The potential relationship between anaesthesia, surgery and onset of dementia remains elusive.
Aims:
To determine whether the risk of dementia increases after surgery with anaesthesia, and to evaluate possible associations among age, mode of anaesthesia, type of surgery and risk of dementia.
Method:
The study cohort comprised patients aged 50 years and older who were anaesthetised for the first time since 1995 between 1 January 2004 and 31 December 2007, and a control group of randomly selected patients matched for age and gender. Patients were followed until 31 December 2010 to identify the emergence of dementia.
Results:
Relative to the control group, patients who underwent anaesthesia and surgery exhibited an increased risk of dementia (hazard ratio = 1.99) and a reduced mean interval to dementia diagnosis. The risk of dementia increased in patients who received intravenous or intramuscular anaesthesia, regional anaesthesia and general anaesthesia.
Conclusions:
The results of our nationwide, population-based study suggest that patients who undergo anaesthesia and surgery may be at increased risk of dementia.
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