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Thrombotic thrombocytopenic purpura in a patient with interferon treated hepatitis C successfully treated with

Nishant Poddar1, Jen C Wang

  • 1Division of Hematology/Oncology, Brookdale University Hospital Medical Center , Brooklyn, NY, USA.

Hematology Reports
|July 27, 2013
PubMed

Thrombotic thrombocytopenic purpura (TTP) is a life threatening condition associated with formation of platelet thrombi. Deficiency of ADAM TS 13 with presence of inhibitory anti-ADAM TS 13 Immunoglobulin G antibody is seen in patients with acquired TTP. TTP in patients on interferon therapy for chronic hepatitis C has rarely been reported. Furthermore, successful treatment of an initial episode of acute refractory acquired TTP, in a patient of chronic hepatitis C during interferon therapy with Rituximab, has not been previously reported. Here we describe a case of acute refractory acquired TTP associated with pegylated interferon therapy for her chronic hepatitis C infection. Initially refractory to plasmapheresis and steroids, she was successfully treated with Rituximab and plasmaphersis without any evidence of reactivation of hepatitis.

Keywords:
Rituximabhepatitis Cinterferonthrombotic thrombocytopenic purpura

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