[Principles of the pharmacological treatment of drug addiction]

Treatment of addiction is extremely eomplex Identification of neurobiological mechanisms involved in this disease has made it possible to identify interesting pharmacological targets in the reward circuit and regions associated with this circuit. Current treatments are based on interactions with the acute effects of the drug on dopaminergic transmission, on the reactivation of the reward circuit in the absence of drug, on the reduction of withdrawal symptoms, or on inter-Sactions with systems associated with the reward circuit. In these systems, neurotransmitters such as GABA, glutamate and endogenous opioids play a crucial role in the development of addiction. In this article, we focus on the pharmacological management of addiction to alcohol, nicotine and opiates.