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Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...
Stimulants01:29

Stimulants

Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Drug Dependence01:17

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...

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Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

[Cocaine addiction].

W Pitchot1, G Scantamburlo, E Pinto

  • 1Service de Psychologie Medicale et de Psychiatrie, CHU de Liege, Belgique. W.Pitchot@chu.ulg.ac.be

Revue Medicale De Liege
|July 30, 2013
PubMed
Summary
This summary is machine-generated.

Cocaine addiction poses significant health risks, affecting both the body and mind. Understanding this highly addictive stimulant is crucial due to its widespread use and severe consequences.

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Last Updated: May 9, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
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Published on: February 18, 2016

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
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Area of Science:

  • Neuroscience
  • Psychiatry
  • Public Health

Context:

  • Cocaine is the second most prevalent illicit drug globally, following cannabis.
  • Its use presents substantial somatic and psychiatric challenges.
  • Rising consumption rates necessitate updated knowledge.

Purpose:

  • To provide a comprehensive overview of cocaine addiction.
  • To highlight the clinical relevance of its consequences.
  • To update current understanding based on increasing consumption.

Summary:

  • Cocaine acts as a potent central nervous system stimulant.
  • It is characterized by a high potential for addiction.
  • Associated health issues are clinically significant and widespread.

Impact:

  • Informs healthcare professionals about the scope of cocaine addiction.
  • Supports public health initiatives by detailing the drug's impact.
  • Provides a foundation for further research into addiction treatment and prevention.