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Related Experiment Video

Updated: May 9, 2026

Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro

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Glutathione in multiple sclerosis.

B Ferreira¹, F Mendes, N Osório

¹Department of Clinical Analysis and Public Health, Coimbra Health School, Polytechnic Institute of Coimbra, Portugal. brigite_f@hotmail.com

British Journal of Biomedical Science

|July 30, 2013

Summary

This summary is machine-generated.

Oxidative stress may play a role in multiple sclerosis (MS). This review examines glutathione

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Area of Science:

Neuroscience
Immunology
Biochemistry

Background:

Multiple sclerosis (MS) is a chronic, autoimmune neurodegenerative disorder of the central nervous system.
The exact cause of MS is unknown but is considered multifactorial, with oxidative stress implicated.
Oxidative stress, a disruption in the oxidant/antioxidant balance, may contribute to MS pathogenesis or be a consequence of the disease.

Purpose of the Study:

To review the role of glutathione, a key endogenous antioxidant, in multiple sclerosis.
To evaluate glutathione and associated enzymes (glutathione peroxidase, glutathione reductase) in various MS forms and stages.
To identify research gaps and suggest future research directions for understanding oxidative stress in MS.

Main Methods:

Literature search and analysis of existing studies on glutathione, oxidative stress, and multiple sclerosis.
Evaluation of scientific literature regarding the oxidant/antioxidant balance in MS patients.
Synthesis of findings to assess the current understanding and identify areas needing further investigation.

Main Results:

The scientific community lacks consensus on the precise role of oxidative stress and glutathione in MS.
Existing studies show varied results regarding glutathione levels and enzyme activity in different MS forms and stages.
The compensatory mechanisms of the body in response to oxidative stress in MS require further elucidation.

Conclusions:

More comprehensive studies are needed to clarify the role of oxidative stress and glutathione in MS pathogenesis.
Identifying reliable biomarkers for MS progression and oxidative stress indicators is crucial.
Further research into potential therapeutic agents, including acrolein, lipoic acid, and dimethyl fumarate, is warranted to improve patient outcomes and quality of life.