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Development of Multiplex Real-Time RT-qPCR Assays for the Detection of SARS-CoV-2, Influenza A/B, and MERS-CoV
Published on: November 10, 2023
Public health investigations required for protecting the population against novel coronaviruses
1Influenza and Other Respiratory Viruses Programme, European Centre for Disease Prevention and Control, Stockholm, Sweden. Angus.Nicoll@ecdc.europa.eu
Abstract:
ABSTRACT There have been many laboratory-based investigations since the emergence of the novel coronaviruses in the autumn of 2012, but most of the parameters required for establishing scientifically the control measures that will protect against them have yet to be determined. Equally, the global distribution of the viruses in their animal reservoir has yet to be established. The experience of investigating and controlling another novel coronavirus, SARS, in 2003 shows how national and local investigations can come together as an international coalition and successfully avert epidemics. A menu of studies that need to be undertaken, especially in the countries experiencing transmission, is presented here.
Insights
Research on novel coronaviruses since 2012 is ongoing, but critical control parameters and animal reservoir distribution remain unknown. Lessons from SARS demonstrate the potential of international collaboration to prevent epidemics.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Numerous laboratory studies have been conducted since the emergence of novel coronaviruses in late 2012.
- Key parameters for scientifically establishing effective control measures are yet to be determined.
- The global distribution of these viruses within their animal reservoirs remains largely unmapped.
Purpose of the Study:
- To highlight the need for further research into novel coronaviruses.
- To identify essential studies required for effective control measure development.
- To emphasize the importance of understanding viral reservoirs and transmission dynamics.
Main Methods:
- Review of existing laboratory investigations.
- Analysis of knowledge gaps in coronavirus control.
- Drawing parallels with the Severe Acute Respiratory Syndrome (SARS) outbreak response.
Main Results:
- Significant gaps exist in understanding the parameters needed for coronavirus control.
- The global animal reservoir and distribution of novel coronaviruses require extensive investigation.
- Past experiences, like SARS, underscore the success of coordinated international efforts.
Conclusions:
- Further targeted studies are crucial, particularly in regions experiencing transmission.
- Establishing control measures necessitates a comprehensive understanding of viral ecology and epidemiology.
- International collaboration is vital for averting widespread outbreaks of novel coronaviruses.
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