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Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

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Related Experiment Video

Updated: May 9, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Interplay between epigenetics & cancer metabolism.

Vibhor Gupta, P Gopinath, Mohd Askandar Iqbal

¹National Center of Applied Human Genetics, School of Life Science, Jawaharlal Nehru University, New Delhi-110067, India. vibhorg@mail.med.upenn.edu.

Current Pharmaceutical Design

|July 30, 2013

Summary

Cancer cells reprogram metabolism for growth, influencing epigenetic changes. Understanding this crosstalk is key for developing novel anti-cancer strategies targeting both metabolism and epigenetics.

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Last Updated: May 9, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

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Published on: January 2, 2009

Area of Science:

Cellular Metabolism
Cancer Biology
Epigenetics

Background:

Cell proliferation requires significant nutrient utilization and biosynthetic capacity.
Metabolic reprogramming, driven by oncogenic pathways, supports cancer cell growth and division.
Epigenetic mechanisms and cellular metabolism are increasingly recognized as interconnected in cancer.

Purpose of the Study:

To explore the regulatory role of cellular metabolism on the epigenome in cancer.
To investigate how epigenetic alterations contribute to cancer-specific metabolic phenotypes.
To highlight the therapeutic potential of targeting the metabolism-epigenetics crosstalk in cancer.

Main Methods:

Review of current literature on metabolic reprogramming in cancer.
Analysis of signaling pathways and transcription factors influencing metabolic enzymes.
Examination of evidence for metabolic effects on epigenetic modifications.

Main Results:

Altered nutrient utilization and glycolytic enzyme activity are hallmarks of proliferating and cancer cells.
Oncogenic signaling pathways are major drivers of metabolic reprogramming in cancer.
Metabolic alterations can impact epigenetic regulation, and vice versa, creating a feedback loop.

Conclusions:

The interplay between cellular metabolism and epigenetics is crucial for cancer development and progression.
Targeting this crosstalk offers promising avenues for novel anti-cancer therapies.
Further research into the metabolism-epigenetics relationship is essential for advancing cancer treatment.