Related Experiment Video
Updated: May 9, 2026

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
Published on: April 28, 2022
Differentiating adolescent suicide attempters from ideators: examining the interaction between depression severity
Kimberly H McManama O'Brien1, Sara J Becker, Anthony Spirito
1Department of Psychiatry and Human Behavior, Center for Alcohol and Addiction Studies, Alpert Medical School of Brown University, Providence RI, USA.
Abstract:
Depressed mood, frequency of alcohol use, and their combination were examined to see if they differentiated nonsuicidal adolescents from those with suicidal ideation and adolescents with suicidal ideation from those who have made a suicide attempt. Hierarchical logistic regressions indicated that frequency of alcohol use did not differentiate nonsuicidal adolescents from those with current suicidal ideation, but severity of depressed mood did so. In contrast, alcohol use was a significant differentiating factor between adolescents who had attempted suicide compared to those with suicidal ideation only, with severity of depressed mood not being significant. However, there was also a significant interaction effect such that for adolescents with suicidal ideation and low levels of depression, increased frequency of alcohol use was associated with increased odds of a suicide attempt. These findings suggest that alcohol use may hasten the transition from suicidal ideation to suicide attempt in adolescents with low levels of depressed mood.
Related Concept Videos
Self-Presentation: Self-Monitoring and Self-Handicapping
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
CNS Depressants: Alcohol and Nicotine
Depressants
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
Depression: Overview
Antidepressant Drugs: MAOIs and Other Agents

