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Related Experiment Video

Updated: May 9, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Dried apples enriched with mandarin juice by vacuum impregnation improve antioxidant capacity and decrease

Pilar Codoñer-Franch1, Ester Betoret, Noelia Betoret

  • 1Department of Pediatrics, Dr. Peset University Hospital, Valencia, Spain. pilar.codoner@uv.es

Nutricion Hospitalaria
|July 30, 2013
PubMed
Summary

A novel apple and mandarin food product improved antioxidant status and reduced inflammation in obese children. This dietary addition also positively impacted blood pressure and lipid profiles, suggesting benefits for atherosclerosis risk factors.

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Last Updated: May 9, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Area of Science:

  • Nutrition Science
  • Pediatric Obesity
  • Oxidative Stress Research

Background:

  • Adequate fruit and vegetable intake is linked to reduced degenerative disease risk due to antioxidants.
  • Obesity is associated with increased oxidative stress and inflammation.
  • Novel food products can be explored to deliver beneficial compounds.

Purpose of the Study:

  • To evaluate the in vivo effects of a novel dried apple product enriched with mandarin juice on oxidant status and inflammation in obese children.
  • To assess the impact of the product on metabolic risk factors and anthropometric parameters.

Main Methods:

  • A four-week intervention study involving 41 obese children was conducted.
  • Participants consumed 40 g/day of the developed apple-mandarin product alongside their usual diet.
  • Measurements included anthropometrics, dietary intake, blood pressure, lipid profile, glucose, insulin resistance, plasma antioxidant capacity, DNA oxidative damage markers, and inflammatory markers.

Main Results:

  • Significant improvements were observed in systolic blood pressure and lipid profiles.
  • Plasma antioxidant capacity significantly increased, while markers of DNA oxidative damage and inflammation decreased.
  • No significant changes in anthropometric parameters were reported.

Conclusions:

  • Supplementing the diet of obese children with the novel apple-mandarin product helps improve their oxidant and inflammatory status.
  • The product consumption contributed to ameliorating several risk factors associated with atherosclerosis.
  • This intervention highlights a potential dietary strategy for managing health risks in pediatric obesity.