Related Experiment Video
Updated: May 9, 2026

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
Published on: October 3, 2025
Understanding cellular function and disease with comparative pathway analysis
Melissa J Davis1, Mark A Ragan1
1The University of Queensland, Institute for Molecular Bioscience, ARC Centre of Excellence in Bioinformatics, St Lucia, Queensland 4072, Australia.
Abstract:
Pathway analysis is important in interpreting the functional implications of high-throughput experimental results, but robust comparison across platforms and species is problematic. A new approach, Pathprinting, provides a cross-platform, cross-species comparative analysis of pathway expression signatures. This method calculates pathway-level statistics from gene expression across nearly 180,000 microarrays in the Gene Expression Omnibus. Pathprinting can accurately retrieve phenotypically similar samples and identify sets of human and mouse genes that are prognostic in cancer. See related Research paper, http://genomemedicine.com/content/5/7/68.
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