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Updated: May 9, 2026

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Tandem modifications of an epoxyquinone C7N pharmacophore
1State Key Laboratory of Microbial Metabolism and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China. bailq@sjtu.edu.cn
Abstract:
C7N moieties are wildly present as pharmacophores in natural products. In this issue of Chemistry & Biology, Rui and colleagues biochemically reproduced the initiation event of asukamycin biosynthesis and characterized tandem enzymatic oxygenations of the epoxyquinone C7N moiety.
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