Stem cell-based treatment in geographic atrophy: promises and pitfalls
Anders Kvanta1, Monika K Grudzinska
1Department of Vitreoretinal Diseases, St. Erik Eye Hospital and Karolinska Institutet, Stockholm, Sweden.
Abstract:
Geographic atrophy is a common and untreatable form of advanced age-related macular degeneration. The degeneration primarily affects the retinal pigment epithelium and photoreceptors of the retina and their restoration by cell transplantation seems attractive. Recently, a patient with geographic atrophy was the first human to receive cells derived from human embryonic stem cells. In this short review, the rationale, potential and obstacles for stem cell-derived therapy in geographic atrophy are discussed.
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