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Linear and micronodular neuroendocrine cell hyperplasia in an ovarian mucinous cystadenoma
Emanuele Dainese1, Laura Cimetti, Carlo Capella
1Surgical Pathology Division, Department of Laboratory, A. Manzoni Hospital, Lecco, Italy.
Abstract:
We report a rare case of an ovarian mucinous cystadenoma in which there were peculiar neuroendocrine micronests composed of gastrin-immunoreactive cells. There was no clinical evidence of hypergastrinemia. The mucinous component of the neoplasm was represented by columnar cells mostly expressing a gastric phenotype with MUC5AC and claudin 18 positivity, which was consistent with the presence of interspersed gastrin cells. The tumoral stroma displayed areas of luteinization with cells intensely positive for α-inhibin, MART-1 and calretinin.
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