Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase

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Ayşe Selcen Alpan1, Sülünay Parlar, Luca Carlino

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, 35100 Bornova, Izmir, Turkey.

Bioorganic & Medicinal Chemistry
|July 30, 2013
PubMed

Keywords:
1H-Benzimidazole5,5′-dithiobis(2-nitrobenzoic acid)AChEAChEIADATCAcetylcholinesterase inhibitorAlzheimer’s diseaseAβBuChEButyrylcholinesterase inhibitorCASDTNBElectrophorus electricus AChEMDMolecular modelingPASRMSDSynthesisTcAChETorpedo californica AChEacetylcholinesteraseacetylcholinesterase inhibitorsacetylthiocholine iodidebutyrylcholinesterasecatalytic active siteeeAChEhAChEhuman AChEmolecular dynamicsperipheral anionic siteroot mean square deviationβ-amyloid

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