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Aneurysms of medium-sized arteries in Marfan syndrome

Mazen Awais1, David M Williams, G Michael Deeb

  • 1University of Michigan Cardiovascular Center, Ann Arbor, MI.

Annals of Vascular Surgery
|July 30, 2013
PubMed

Insights

Marfan syndrome, a connective tissue disorder, is linked to large artery aneurysms. This study explores its potential association with small- to medium-sized artery aneurysms, requiring further investigation.

Area of Science:

  • Vascular Medicine
  • Genetics
  • Connective Tissue Disorders

Background:

  • Marfan syndrome is a genetic disorder affecting connective tissue, primarily known for cardiovascular complications like aortic aneurysm and dissection.
  • While Marfan syndrome is associated with large artery aneurysms, its link to small- to medium-sized artery aneurysms remains unclear.

Observation:

  • This report details four patients diagnosed with Marfan syndrome who also presented with small- to medium-sized artery aneurysms.
  • These patients experienced several complications related to these aneurysms.

Findings:

  • The study highlights a potential, yet unconfirmed, association between Marfan syndrome and the development of small- to medium-sized artery aneurysms.
  • Complications arising from these aneurysms in Marfan syndrome patients were observed.

Implications:

  • Further research is crucial to establish a causal link between Marfan syndrome and small- to medium-sized artery aneurysms.
  • Investigating optimal treatment strategies for patients with both Marfan syndrome and small- to medium-sized artery aneurysms is necessary.

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