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Updated: May 9, 2026
10:10
Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
Published on: February 16, 2017
Musculoskeletal ageing and primary prevention.
Anders Nedergaard1, Kim Henriksen, Morten A Karsdal
1Nordic Bioscience Biomarkers and Research, Herlev Hovedgade 207, 2720 Herlev, Denmark; Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Building 8, Bispebjerg Bakke 23, 2400 Copenhagen NW, Denmark.
Summary
Ageing naturally reduces bone and muscle mass and function. Lifestyle changes are key, but pharmacological interventions may be crucial for preventing age-related musculoskeletal decline.
Area of Science:
- Gerontology and musculoskeletal health.
Background:
- Musculoskeletal mass and function decline naturally with age, exacerbated by lifestyle factors.
- Osteoporosis and sarcopaenia prevalence is rising due to increased lifespan.
- Public health interventions for lifestyle changes have low compliance, limiting effectiveness.
Purpose of the Study:
- To review the biology of musculoskeletal ageing.
- To explore preventative measures against age-associated musculoskeletal decline.
- To emphasize the potential of pharmacological interventions.
Main Methods:
- Literature review of musculoskeletal ageing biology.
- Analysis of preventative strategies for bone and muscle loss.
- Focus on pharmacological approaches for primary prevention.
Main Results:
- Ageing inherently leads to musculoskeletal deterioration.
- Lifestyle modifications are effective but compliance is a challenge.
- Pharmacological strategies are proposed as a future primary prevention.
Conclusions:
- Musculoskeletal ageing necessitates effective prevention strategies.
- Pharmacological interventions are likely to be central to future primary prevention efforts.
- Addressing age-related bone and muscle loss requires innovative approaches.
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