Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Base Pairing02:27

DNA Base Pairing

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
DNA Base Pairing02:27

DNA Base Pairing

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
Base-pairing and DNA Repair02:27

Base-pairing and DNA Repair

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
Nucleic acids02:43

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic Acids02:43

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nanostructured lipopeptide-based membranomimetics for stabilizing bacteriorhodopsin.

Biomaterials science·2024
Same author

Base pair compositional variability influences DNA structural stability and tunes hydration thermodynamics and dynamics.

The Journal of chemical physics·2023
Same author

Microscopic model on indoor propagation of respiratory droplets.

Computational biology and chemistry·2023
Same author

Slower diffusion and anomalous association of R453W lamin A protein alter nuclear architecture in AD-EDMD.

RSC advances·2022
Same author

RNABPDB: Molecular Modeling of RNA Structure-From Base Pair Analysis in Crystals to Structure Prediction.

Interdisciplinary sciences, computational life sciences·2022
Same author

MetBP: a software tool for detection of interaction between metal ion-RNA base pairs.

Bioinformatics (Oxford, England)·2022
Same journal

Mathematical frameworks for left ventricular assist device therapy: Ventricular mechanics, blood rheology, haemodynamics, control, and nonlinear dynamics.

Progress in biophysics and molecular biology·2026
Same journal

Biological functions of BAF57, its role in disease pathogenesis, and treatment: From molecular mechanisms to clinical translation.

Progress in biophysics and molecular biology·2026
Same journal

Photonics-integrated and AI-enhanced medical sensing: From molecular diagnostics to real-time cell therapy monitoring.

Progress in biophysics and molecular biology·2026
Same journal

Uncovering the Biological Mechanisms of TREM2 with Molecular Simulations: A Comprehensive Review and Perspective.

Progress in biophysics and molecular biology·2026
Same journal

Advances in artificial joint testing driven by in situ mechanical characterization: From permeability of porous structures to dynamic wear monitoring.

Progress in biophysics and molecular biology·2026
Same journal

Proteostasis-driven redox adaptation in ferroptosis: the p62-Keap1-Nrf2 axis.

Progress in biophysics and molecular biology·2026
See all related articles

Related Experiment Video

Updated: May 9, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

RNA structure and dynamics: a base pairing perspective.

Sukanya Halder1, Dhananjay Bhattacharyya

  • 1Biophysics division, Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, Kolkata 700 064, India.

Progress in Biophysics and Molecular Biology
|July 30, 2013
PubMed
Summary
This summary is machine-generated.

Non-canonical base pairs are crucial for RNA structure and function, stabilizing molecules through unique hydrogen bonding. Understanding these pairs enhances RNA structure prediction accuracy.

Keywords:
Detection of non-canonical base pairsNon-canonical base pairRNA secondary structureStructural characterization of non-canonical base pairs

More Related Videos

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

Related Experiment Videos

Last Updated: May 9, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • Functional RNA molecules rely on intricate three-dimensional structures.
  • These structures are formed by base pairing, including canonical and non-canonical interactions.
  • Non-canonical base pairs stabilize RNA through long-range interactions and influence molecular function.

Purpose of the Study:

  • To review the structural aspects of non-canonical base pairs in RNA organization.
  • To explore the role of these pairs in stabilizing RNA molecules.
  • To discuss applications in improving RNA structure prediction.

Main Methods:

  • Analysis of theoretical studies on non-canonical base pairs.
  • Examination of ab initio quantum chemical methods.
  • Inclusion of molecular dynamics simulations of RNA fragments.

Main Results:

  • Non-canonical base pairs are formed via edge-to-edge hydrogen bonding.
  • These pairs are integral to structural motifs like helices and loops.
  • Many non-canonical pairs exhibit stability comparable to Watson-Crick pairs.

Conclusions:

  • Non-canonical base pairs are essential for RNA structural integrity and function.
  • Their unique interactions contribute significantly to molecular stability.
  • Further study of these pairs can lead to more accurate RNA structure prediction models.