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The adenosine A(2A) antagonistic properties of selected C8-substituted xanthines

Mietha M Van der Walt1, Gisella Terre'Blanche, Anél Petzer

  • 1Pharmaceutical Chemistry, School of Pharmacy, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.

Bioorganic Chemistry
|July 30, 2013
PubMed

Keywords:
(E)-8-(3-chlorostyryl)caffeine1,3-[(3)H]-dipropyl-8-cyclopentylxanthine1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineAdenosine A(2A) receptorsAntagonismCNSCPACSCDMFDMSOEDACGPCRHaloperidol-induced catalepsyMAO-BMPTPN,N-dimethylformamideN-(3-dimethylaminopropyl)-N′-ethylcarbodiimideN-[(3)H]ethyladenosin-5′-uronamideParkinson’s diseaseSARSIXanthine[(3)H]DPCPX[(3)H]NECAcentral nervous systemcyclopentyladenosinedimethyl sulfoxideguanine nucleotide-binding protein (G protein)-coupled receptormonoamine oxidase Bselectivity indexstructure–activity relationship

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