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[High-efficiency membranes and the dialysis solution].

S Agliata1, G Airoldi, A Baroni

  • 1Ospedale Civile, Borgomanero, Divisione Nefrologia e Dialisi.

Minerva Urologica E Nefrologica = the Italian Journal of Urology and Nephrology
|January 1, 1990
PubMed
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Bacterial contamination in liquid bicarbonate concentrate is high, influenced by production and storage. This contamination impacts patient hemodialysis, correlating with lower blood pressure.

Area of Science:

  • Nephrology
  • Microbiology
  • Clinical Chemistry

Background:

  • Liquid bicarbonate concentrate is crucial for hemodialysis.
  • Bacterial contamination of dialysates can pose risks to patients.

Purpose of the Study:

  • To determine bacterial pollution in liquid bicarbonate concentrate.
  • To assess the impact of production and storage on contamination.
  • To investigate the clinical influence of bacterial contamination on hemodialysis patients.

Main Methods:

  • Total bacterial count and Pseudomonas detection.
  • Limulus Amebocyte Lysate test for endotoxins.
  • Monitoring cardiac rate and systemic arterial pressure.

Main Results:

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  • Elevated bacterial contamination levels were found in the liquid bicarbonate concentrate.
  • Production and storage procedures significantly affect contamination levels.
  • An inverse correlation was observed between systemic arterial pressure and dialysate endotoxin levels.

Conclusions:

  • Liquid bicarbonate concentrate is prone to significant bacterial contamination.
  • Production and storage conditions are critical factors influencing contamination.
  • Bacterial contamination, indicated by endotoxin levels, impacts patient hemodynamics during dialysis.