Related Experiment Video

Updated: May 9, 2026

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
09:07

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

Published on: December 19, 2018

Valproic acid and its derivatives enhanced estrogenic activity but not androgenic activity in a structure dependent

Sandra Stempin1, Susanne Andres, Maja Bumke Scheer

  • 1BfR - Federal Institute for Risk Assessment, Department of Food Safety, Berlin, Germany.

Reproductive Toxicology (Elmsford, N.Y.)
|July 30, 2013
PubMed

Keywords:
17β-estradiol2-(2-propynyl)-heptanoic acid2-(2-propynyl)-hexanoic acid2-(2-propynyl)-nonanoic acid2-ethyl-4-pentynoic acid2-n-propyl-2-pentenoic acid5α-dihydrotestosteroneAP-1ARAndrogen receptor (AR)DHTE(2)E-2-en-VPAERERαERβEstrogen receptor (ER)HDACHEK293Human Embryonic Kidney 293 cellsLuciferase reporter gene assayS-pentyl-4-yn-VPATeratogenicityVPAVPA derivativesValproic acid (VPA)activator protein 1androgen receptorbutyl-4-yn-VPAestrogen receptorethyl-4-yn-VPAheptyl-4-yn-VPAhistone deacetylasevalproic acid (2-propylpentanoic acid)

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