Thigh circumference and diabetes: obesity as a potential effect modifier
Keum Ji Jung1, Heejin Kimm, Ji Eun Yun
1Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea.
Journal of Epidemiology
|July 30, 2013
Summary
Smaller thigh circumference is linked to a higher diabetes risk, particularly in leaner individuals. This finding highlights thigh circumference as a potential indicator for diabetes.
Area of Science:
- Endocrinology
- Metabolic Health
- Public Health
Background:
- Thigh circumference is a known risk factor for type 2 diabetes.
- The modifying effect of obesity on this association requires further investigation.
Purpose of the Study:
- To examine the relationship between thigh circumference and diabetes risk.
- To investigate the role of body mass index (BMI) as an effect modifier in this association.
Main Methods:
- Cross-sectional study of 384,612 Korean adults aged 30-79 years.
- Multivariate logistic regression analysis was used to assess the association between diabetes and thigh circumference, stratified by BMI.
- Thigh circumference was analyzed across nine percentile categories, with separate analyses for men and women.
Main Results:
- A smaller thigh circumference was associated with an increased risk of diabetes in both men and women.
- This association was more pronounced in individuals with a body mass index (BMI) below 25 kg/m(2).
- Body mass index (BMI) significantly modified the association between thigh circumference and diabetes risk, especially in men.
Conclusions:
- Reduced thigh circumference is a significant indicator of elevated diabetes risk, particularly in individuals with a BMI less than 25 kg/m(2).
- Thigh circumference may serve as a valuable screening tool for diabetes, especially in non-obese populations.
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