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Related Experiment Video

Updated: May 9, 2026

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

Silicon nanowire based single-molecule SERS sensor.

Hui Wang¹, Xuemei Han, Xuemei Ou

¹Nano-organic Photoelectronic Laboratory and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.

|July 30, 2013

Summary

This summary is machine-generated.

This study demonstrates single molecule detection using silver nanoparticle-decorated silicon nanowire (AgNP-SiNW) sensors. This breakthrough advances nanowire optical sensors for molecular-level biological probing.

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Area of Science:

Nanotechnology
Optical Sensing
Biophysics

Background:

One-dimensional nanowire (NW) optical sensors are valuable nanoscale tools for biological applications, including intracellular probing.
Achieving single molecule detection (SMD) on NW sensors is a significant challenge in the field.

Purpose of the Study:

To investigate the capability of single silicon nanowire (SiNW) based surface-enhanced Raman scattering (SERS) sensors for single molecule detection.
To explore the sensing mechanism of NW sensors at the molecular level.

Main Methods:

Fabrication of a single SiNW sensor by depositing silver nanoparticles (AgNPs) onto a SiNW (AgNP-SiNW).
Utilizing Raman spectral blinking and bi-analyte approaches in aqueous solution to assess SMD.
Employing surface-enhanced Raman scattering (SERS) for sensitive detection.

Main Results:

Demonstrated successful single molecule detection (SMD) on individual AgNP-SiNW SERS sensors.
Observed and analyzed Raman spectral blinking phenomena for SMD confirmation.
Investigated sensor performance using a bi-analyte approach in aqueous environments.

Conclusions:

The SiNW sensor, functionalized with AgNPs, is capable of single molecule detection.
This research extends the functionality of SiNW sensors to SMD.
Provides molecular-level insights into the sensing mechanisms of nanowire-based SERS sensors.