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Updated: May 9, 2026
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Published on: September 26, 2018
Comparison of cardiovascular risk calculation tools in pharmacy practice
Nicole D White1, Thomas L Lenz, Maryann Z Skrabal
1School of Pharmacy and Health Professions, Creighton University, Omaha, NE 68178, USA. nicolewhite@creighton.edu
Objective:
To examine the use of various cardiovascular disease (CVD) risk estimation calculators in pharmacy practice.
Design:
Longitudinal cohort study.
Setting:
Midwestern university worksite from August 2008 through May 2012.
Participants:
University employees with hypertension, dyslipidemia, and diabetes.
Intervention:
Risk estimation calculators were applied to data from a pharmacist-run chronic disease management program.
Main Outcome Measure:
Difference in estimated CVD risk from multiple estimation calculators.
Results:
At baseline and 12 months, non-lab-based tools reported significantly higher 10-year CVD risk percentages compared with lab-based tools among the same cohort of patients (10.63% vs. 8.71% at baseline, P < 0.001; 9.34% vs. 7.31% at 12 months, P < 0.001). In addition, the electronic version of 10-year CVD risk reported significantly higher values than the paper version when applied to the same patient cohort (7.31% vs. 6.60% at 12 months, P = 0.018).
Conclusion:
CVD risk estimation tools report significantly different values and are not interchangeable. Pharmacists using non-lab-based tools should expect significantly higher risk estimates than estimates derived from lab-based tools and therefore should use the same version of the estimation tool over the long term.
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