Related Experiment Video
Updated: May 9, 2026
08:13
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
Published on: January 7, 2018
Metabolic syndrome and glucose tolerance status
Huseyin Cat1, Ali Osman Ozturk, Berrin Karadag
1Department of Internal Medicine, Sisli Etfal Training and Research Hospital Sisli, Istanbul; Turkey.
Summary
The oral glucose tolerance test (OGTT) is valuable for identifying prediabetic individuals within metabolic syndrome (MetS) patient groups. This early detection is crucial for timely intervention in non-diabetic patients with MetS.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Diabetes Research
Background:
- Metabolic syndrome (MetS) is a cluster of conditions increasing cardiovascular and diabetes risk.
- Early identification of glucose metabolism abnormalities is vital for preventing progression to type 2 diabetes.
- The utility of the oral glucose tolerance test (OGTT) in non-diabetic individuals with MetS requires further investigation.
Purpose of the Study:
- To evaluate the diagnostic value of the oral glucose tolerance test (OGTT) in non-diabetic patients diagnosed with metabolic syndrome (MetS).
Main Methods:
- A cohort of 398 patients attending outpatient clinics were assessed.
- Patients were classified as having MetS based on International Diabetes Federation (IDF) criteria.
- The oral glucose tolerance test (OGTT) was administered to eligible non-diabetic patients.
Main Results:
- Out of 398 patients, 7 (2%) were diagnosed with diabetes, 119 (30%) with impaired glucose tolerance (IGT), and 272 (68%) had normal glucose tolerance.
- No significant differences in height, weight, waist circumference, fasting glycemia, or high-density cholesterol levels were observed between the IGT and non-IGT groups.
Conclusions:
- The oral glucose tolerance test (OGTT) is a necessary tool for detecting early prediabetic states in non-diabetic patients with metabolic syndrome.
- Identifying patients with impaired glucose tolerance (IGT) is critical for implementing preventative strategies against type 2 diabetes.
Related Concept Videos
01:19Overview of Carbohydrate Metabolism
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
01:24Type II Diabetes II: Pathophysiology
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
01:26Type II Diabetes I: Introduction
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
01:22Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
01:25Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
01:29Hyperglycemia
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...