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Published on: September 27, 2019
The relationship between coenzyme Q10 and severity of coronary artery disease
Eyüp Büyükkaya1, Osman Evliyaoğlu, Yahya Islamoğlu
11Department of Cardiology , School of Medicine of Mustafa Kemal University, Hatay, 2Department of Medical Biochemistry, School of Medicine of Dicle University, Diyarbakır, 3Department of Cardiology, School of Medicine of Dicle University, Diyarbakır; Turkey.
Insights
Serum coenzyme Q10 (CoQ10) levels are lower in patients with coronary artery disease (CAD). However, CoQ10 levels do not correlate with the severity of coronary atherosclerosis in patients with stable angina.
Area of Science:
- Cardiology
- Biochemistry
- Nutritional Science
Background:
- Coenzyme Q10 (CoQ10) is a vital antioxidant involved in cellular energy production.
- Oxidative stress plays a role in the pathogenesis of coronary artery disease (CAD).
Purpose of the Study:
- To investigate the association between plasma CoQ10 levels and the severity of coronary atherosclerosis.
- To determine if CoQ10 levels correlate with Gensini scores in patients with CAD.
Main Methods:
- Serum CoQ10, lipid profiles, and Gensini scores were assessed in 113 subjects (83 with CAD, 30 controls).
- CAD severity was categorized using the Gensini scoring system.
- Statistical analyses compared CoQ10 levels across different severity groups and controls.
Main Results:
- Serum CoQ10 levels and CoQ10 ratios (CoQ10/TC, CoQ10/LDL-C, CoQ10/TG) were significantly lower in patients with mild and severe CAD compared to controls.
- No significant differences in serum CoQ10 levels or ratios were observed between the mild and severe CAD groups.
Conclusions:
- While serum CoQ10 levels are reduced in stable CAD patients, they do not appear to be directly related to the severity of coronary atherosclerosis.
- Further research may explore the therapeutic potential of CoQ10 in CAD management.
Aim:
To evaluate the relationship between the levels of plasma coenzyme Q10 (CoQ10), a known antioxidant, and severity of the coronary atherosclerosis (AS) measured by Gensini score.
Methods:
Patients with coronary artery disease (CAD) were enrolled to the study between 2010 and 2011 in cardiology outpatient clinics. They were admitted for diagnostic coronary angiography or angioplasty for typical indications. The Gensini scoring system was used to calculate CAD severity. Serum CoQ10, total cholesterol (TC), HDL cholesterol, LDL cholesterol, and triglyceride levels were assessed.
Results:
One hundred thirteen subjects (83 CAD, 30 controls) were included. The patients with CAD were separated into three groups according to Gensini score. The serum levels of CoQ10, CoQ10/ TC, CoQ10/LDL-C, CoQ10/TG rates in the subjects of mild and severe AS groups were significantly lower than the control group ( p less than 0.016 for all control vs. AS group comparisons). There were no significant differences in serum levels of CoQ10 and CoQ10/ TC, CoQ10/LDL-C, CoQ10/TG rates between the mild and severe AS groups.
Conclusion:
This study revealed that although the serum CoQ10 levels were lower in stable CAD, there was no relationship between the severity of CAD and serum CoQ10 levels in patients with stable angina pectoris.
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