Mast cells numbers and peritumoral microvessel density of the prostatic adenocarcinomas and correlation with
Havva Erdem1, M Ali Kayikci, Murat Oktay
11Department of Pathology, 2Department of Urology; Medical Faculty, Duzce University, Duzce, 3Department of Pathology, Erzurum Region Education and Research Hospital, Erzurum, 4Department of Biostatistics, Duzce University, Medical Faculty, Duzce, 5Department of Pathology, Medicine Faculty of Atatürk University, Erzurum; Turkey.
Aim:
To determine the utility of mast cell numbers and microvascular density (MVD) in evaluating acinar type of prostatic adenocarcinoma (PCa), and to ascertain a relationship between the number of mast cells with prognostic parameters (larger tumor volume, high Gleason score, lymphovascular, perineural, seminal vesicles invasion, metastatic lymph node).
Methods:
The study comprised 97 radical prostatectomy specimens. The paraffin sections were stained with anti-CD31, anti- CD34 and Toluidine Blue. The numbers of positive staining of cells and microvessels in 10 high-power fields were counted systematically.
Results:
A statistically significant relationship was found between MVDn and number of MC (r=0.218 and p=0. 032). There was no correlation between age and MC and MVD (p=0.406 and p=0.671, respectively).
Conclusion:
A correlation between mast cell number and microvascular density cannot depend on tumor angiogenesis or this relationship can be an independent parameter. More comprehensive studies could reveal relationship with prognostic parameters.
