Celiac disease associated with autoimmune hepatitis and autoimmune hyperthyroidism

Area of Science:

• Immunology
• Gastroenterology
• Endocrinology

Background:

• Celiac disease (CD) is an immune-mediated disorder triggered by gluten ingestion.
• While CD can co-occur with other autoimmune conditions, multiple simultaneous autoimmune diseases are uncommon.
• This case presents a diagnostic challenge in a patient with a known history of celiac disease.

Purpose of the Study:

• To report a rare case of celiac disease coexisting with autoimmune hepatitis and autoimmune thyroid disease.
• To emphasize the importance of investigating other autoimmune disorders in patients diagnosed with celiac disease.

Main Methods:

• Case report of a 23-year-old female patient.
• Diagnostic workup included laboratory tests (liver function tests, thyroid function tests, autoantibodies) and liver biopsy.
• Treatment involved immunosuppressive therapy.

Main Results:

• The patient, previously diagnosed with celiac disease, presented with jaundice and diarrhea.
• Investigations confirmed concurrent autoimmune hepatitis and autoimmune thyroid disease.
• Immunosuppressive treatment resulted in normalized liver enzymes and bilirubin levels.

Conclusions:

• Celiac disease patients may present with multiple, concurrent autoimmune diseases.
• Autoimmune hepatitis and autoimmune thyroid disease should be considered in celiac disease patients with relevant symptoms.
• Comprehensive autoimmune screening is recommended for patients with celiac disease.