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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma: Overview

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Accessory Structures of the Eye

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Related Experiment Video

Updated: May 9, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Lyonization in ophthalmology.

Wadakarn Wuthisiri1, Michelle D Lingao, Jenina E Capasso

  • 1Wills Eye Institute, Philadelphia, Pennsylvania 19107, USA.

Current Opinion in Ophthalmology
|July 30, 2013
PubMed
Summary
This summary is machine-generated.

Lyonization, the inactivation of one X chromosome, can manifest in various X-linked ocular diseases. Recognizing these ocular signs aids in diagnosing conditions like choroideremia and retinitis pigmentosa in carriers and affected relatives.

Related Experiment Videos

Last Updated: May 9, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Area of Science:

  • Ophthalmology
  • Genetics
  • Molecular Biology

Background:

  • Lyonization is the genetic process of X-chromosome inactivation in female mammals.
  • X-linked ocular diseases affect males predominantly, while female carriers may exhibit variable phenotypes.
  • Understanding Lyonization's ocular manifestations is crucial for accurate diagnosis and genetic counseling.

Purpose of the Study:

  • To elucidate the role and implications of Lyonization in ocular diseases.
  • To highlight clinical findings associated with Lyonization in X-linked eye conditions.
  • To discuss the impact of Lyonization on genetic counseling for affected families.

Main Methods:

  • Review of existing literature on Lyonization and X-linked ocular disorders.
  • Analysis of clinical presentations and diagnostic findings in affected individuals.
  • Correlation of ocular signs with genetic testing and carrier status.

Main Results:

  • Lyonization signs are observable in conditions like choroideremia, X-linked retinitis pigmentosa, and X-linked ocular albinism.
  • Ocular examination and diagnostic tests can reveal Lyonization patterns.
  • These findings assist in diagnosing ocular diseases in female carriers and their male relatives.

Conclusions:

  • Ocular manifestations of Lyonization are valuable diagnostic indicators for X-linked eye diseases.
  • Accurate diagnosis facilitates appropriate molecular genetic testing.
  • Understanding Lyonization improves genetic counseling and patient management.