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Related Experiment Video

Updated: May 9, 2026

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

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Published on: April 15, 2015

Prefrontal cortical microcircuits bind perception to executive control.

Ioan Opris¹, Lucas Santos, Greg A Gerhardt

¹Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, USA. ioopris@wfubmc.edu

Scientific Reports

|July 30, 2013

Summary

This summary is machine-generated.

Prefrontal cortical microcircuits are crucial for guiding goal-driven behavior by integrating perception and executive control. Stimulating specific prefrontal layers causally influences behavior, demonstrating their role in the perception-to-action cycle.

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Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

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Published on: May 24, 2020

Area of Science:

Neuroscience
Cognitive Neuroscience
Primate Research

Background:

The cerebral cortex integrates environmental interactions with perceptual-executive brain systems.
Prefrontal cortical microcircuits are hypothesized to bind perceptual and executive control information for goal-driven behavior.

Purpose of the Study:

To test the hypothesis that prefrontal cortical microcircuits bind perceptual and executive control information.
To investigate the causal role of inter-laminar prefrontal microcircuits in the perception-to-action cycle.

Main Methods:

Simultaneously recorded neuron firing in prefrontal cortical layers and caudate-putamen of rhesus monkeys.
Monkeys were trained on a spatial-versus-object, rule-based match-to-sample task.
Prefrontal infra-granular-layers were stimulated with patterns derived from supra-granular-layers.

Main Results:

Cell firing in prefrontal layers and caudate-putamen showed similar location preferences during perception and executive selection on spatial trials, but less so on object trials.
Stimulation of prefrontal infra-granular-layers induced spatial preference in performance on spatial trials, mimicking neural tuning.
Demonstrated a causal link between inter-laminar prefrontal microcircuits and behavioral outcomes.

Conclusions:

Inter-laminar prefrontal microcircuits play a causal role in the perception-to-action cycle.
Prefrontal microcircuits are essential for integrating sensory information with executive control to guide behavior.