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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Ankle Joint01:10

Ankle Joint

The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Bones of the Lower Limb: Tibia and Fibula01:10

Bones of the Lower Limb: Tibia and Fibula

The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...

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Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
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Published on: January 23, 2018

Bone microarchitecture of the talus changes with aging.

Matthias Krause1, Martin Rupprecht, Marcus Mumme

  • 1Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestr. 52, 22529, Hamburg, Germany.

Clinical Orthopaedics and Related Research
|July 30, 2013
PubMed
Summary

Age significantly impacts talar bone structure, with the greatest bone loss occurring in the talar body. These age-related changes are independent of sex and may influence total ankle replacement outcomes.

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Area of Science:

  • Orthopedic research
  • Geriatric bone health
  • Anatomy and histology

Background:

  • Elderly talar fractures are rare, typically from high-impact events.
  • Total ankle replacement failures can stem from talar subsidence, indicating age-related bone loss.
  • Limited data exists on age and sex effects on talar microarchitecture.

Purpose of the Study:

  • To analyze age-related changes in talar trabecular microarchitecture.
  • To investigate sex-based differences in talar microarchitecture.

Main Methods:

  • Sixty human tali from three age groups (20-80 years) were analyzed.
  • Radiography, micro-CT, and histological analysis were employed.
  • Histomorphometric parameters were assessed in the talar body, neck, and head.

Main Results:

  • Significant age-related bone volume loss was observed, most pronounced in the talar body.
  • Moderate bone loss in the talar neck was primarily due to decreased trabecular thickness.
  • Talar microarchitecture changes were found to be independent of sex.

Conclusions:

  • Age-related bone structural changes are concentrated in the talar body, a risk factor for total ankle replacement loosening.
  • The findings suggest dual-energy X-ray absorptiometry evaluation for patient selection prior to total ankle replacement.
  • Understanding these age-related changes is crucial for improving implant longevity and patient outcomes.