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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

Profile and outcome of childhood tuberculosis treated with DOTS--an observational study

Pushpa Panigatti1, Vinod Hanumant Ratageri, Illalu Shivanand

  • 1Department of Pediatrics, Karnataka Institute of Medical Sciences, Hubli, 580021, Karnataka, India.

Indian Journal of Pediatrics
|July 30, 2013
PubMed

Insights

Childhood tuberculosis, particularly extrapulmonary TB, was effectively treated with Directly Observed Treatment Short (DOTS). This regimen showed a 94.6% cure rate with no observed adverse effects from anti-tubercular treatment.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Childhood tuberculosis (TB) presents unique challenges in diagnosis and treatment.
  • The Directly Observed Treatment Short (DOTS) strategy is a cornerstone of global TB control efforts.
  • Understanding the clinical profile and treatment outcomes of pediatric TB is crucial for improving patient care.

Purpose of the Study:

  • To investigate the clinical characteristics and treatment outcomes of childhood tuberculosis managed with the DOTS regimen.
  • To assess the incidence and nature of side effects associated with anti-tubercular treatment (ATT) in children.

Main Methods:

  • A prospective, hospital-based observational study was conducted involving 93 children (0-12 years) diagnosed with TB.
  • Patients received treatment according to the DOTS regimen, adhering to WHO/RNTCP guidelines.
  • Data on demographics, clinical presentation, diagnosis, treatment, and outcomes were collected and analyzed.

Main Results:

  • Extra-pulmonary tuberculosis (EPTB) was more prevalent (62.4%) than pulmonary TB (37.6%).
  • Common symptoms included fever (83.8%) and pallor (75.3%).
  • A high treatment success rate of 94.6% was achieved, with no reported adverse effects from ATT.

Conclusions:

  • The DOTS regimen demonstrated high efficacy in treating childhood tuberculosis, with a significant cure rate.
  • EPTB is a common form of TB in children.
  • The anti-tubercular treatment used in conjunction with DOTS was well-tolerated, showing no adverse effects in this cohort.
Abstract

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