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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...

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Related Experiment Video

Updated: May 9, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Acrylic bone cement: current concept review.

B Magnan1, M Bondi, T Maluta

  • 1Orthopaedic Department, Surgical Center, P. Confortini, University of Verona, Piazzale A. Stefani 1, 37126, Verona, Italy.

Musculoskeletal Surgery
|July 30, 2013
PubMed
Summary
This summary is machine-generated.

Polymethylmethacrylate (PMMA) bone cement is crucial in orthopedic surgery for implant fixation and fracture repair. It also effectively delivers antibiotics for infection treatment and supports bone quality, offering versatile applications.

Related Experiment Videos

Last Updated: May 9, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Area of Science:

  • Orthopedic Surgery
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Acrylic bone cement, specifically Polymethylmethacrylate (PMMA), has a long-standing history in orthopedic applications.
  • PMMA's utility extends beyond ophthalmology and dentistry into orthopedics for implant fixation and fracture repair.
  • It serves as an effective carrier for sustained antibiotic release, crucial for managing orthopedic infections.

Purpose of the Study:

  • To review the diverse applications of PMMA bone cement in orthopedics.
  • To highlight its role in managing chronic joint prosthesis infections through antibiotic-loaded spacers.
  • To explore its use in augmenting fixation for osteoporotic or fractured bone.

Main Methods:

  • Review of existing literature on PMMA bone cement applications in orthopedics.
  • Analysis of PMMA's properties as a drug delivery system for antibiotics.
  • Examination of PMMA's role in fracture repair and implant fixation.

Main Results:

  • PMMA bone cement is widely used for prosthetic implant fixation and repair of osteoporotic, neoplastic, and vertebral fractures.
  • Antibiotic-loaded PMMA spacers are effective in two-stage procedures for chronic joint prosthesis infections, allowing function and drug release.
  • PMMA and calcium phosphate are investigated for augmenting internal fixation in fractures with poor bone quality.

Conclusions:

  • PMMA bone cement offers versatile solutions in orthopedics, from fixation to infection management and bone augmentation.
  • The development of antibiotic spacers has improved outcomes for infected joint prostheses.
  • Ongoing research into acrylic biomaterials continues to offer innovative models and projects for orthopedic applications.