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Updated: May 9, 2026
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Parahemophilia: new insights into factor v deficiency
Nabil Thalji1, Rodney M Camire
1Division of Hematology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Seminars in Thrombosis and Hemostasis
|July 30, 2013
Summary
Severe deficiency in blood coagulation factor V (FV) can cause mild bleeding, contrary to expectations. This review explores rare FV disorders, focusing on platelet FV's role and bleeding tendency modifiers.
Area of Science:
- Hematology
- Hemostasis and Thrombosis
Background:
- Blood coagulation factor V (FV) is crucial for thrombin generation.
- FV exists in both plasma and platelets, impacting coagulation.
- Factor V deficiency, inherited or acquired, typically causes bleeding disorders.
Purpose of the Study:
- To review rare coagulation factor V deficiency.
- To discuss clinical manifestations, diagnosis, and treatment of FV deficiency.
- To highlight the role of platelet FV and other modifiers in bleeding tendencies.
Main Methods:
- Literature review of rare coagulation factor V deficiency.
- Analysis of clinical manifestations, diagnosis, and treatment strategies.
- Discussion of recent advances in understanding platelet FV and bleeding modifiers.
Main Results:
- Some patients with undetectable FV levels exhibit mild bleeding symptoms.
- Platelet FV and other factors may influence bleeding severity in FV deficiency.
- Understanding these modifiers is key to managing bleeding risks.
Conclusions:
- Severe FV deficiency can present with unexpectedly mild bleeding.
- Platelet-derived FV and other modulatory factors are critical.
- Further research into these modifiers is essential for improved patient management.
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