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Updated: May 9, 2026

Genetic Incorporation of Biosynthesized L-dihydroxyphenylalanine (DOPA) and Its Application to Protein Conjugation
Published on: August 24, 2018
Chemical modulation of bioactive compounds via oligopeptide or amino acid conjugation
Seon-Yeong Kwak1, Jin-Kyoung Yang, Jong-Ho Kim
1School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Republic of Korea; Department of Chemical Engineering, Hanyang University, Ansan, 426-791, Republic of Korea.
Abstract:
Conjugation of an oligopeptide or an amino acid to bioactive compounds is one of the simplest chemical modifications to modulate the biological functions of the compounds. Recently, numerous methods have been proposed for the modification of their properties, including the alteration of their chemical and physical properties, and of their original bioactivities. We review the current knowledge of the adaptability of oligopeptide or amino acid conjugation for modulating the biological activities of biomolecules.
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