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Updated: May 9, 2026
08:45
Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
Childhood intussusception: a literature review
James Jiang1, Baoming Jiang, Umesh Parashar
1National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Plos One
|July 30, 2013
Summary
Monitoring intussusception is vital for rotavirus vaccine safety. This review highlights global incidence, diagnosis, and treatment variations, informing surveillance strategies for vaccine programs.
Area of Science:
- Pediatric Gastroenterology and Infectious Diseases
- Vaccine Safety Surveillance
- Public Health Epidemiology
Background:
- Postlicensure studies indicate a causal link between rotavirus vaccines and intussusception.
- Global introduction of rotavirus vaccines necessitates robust safety monitoring for intussusception.
Purpose of the Study:
- To update knowledge on background incidence and clinical management of intussusception in children.
- To inform the implementation of intussusception surveillance for rotavirus vaccine safety.
Main Methods:
- Systematic review of 82 studies published since 2002 on intussusception in children under 18.
- Analysis of incidence by age, seasonality, diagnostic methods, treatment, and case-fatality rates across global regions.
Main Results:
- Mean incidence of intussusception was 74 per 100,000 in infants under 1 year, peaking at 5-7 months; no seasonality observed.
- Radiographic diagnosis exceeded 95% globally, except in Africa (65%).
- Surgical rates (13-86%) and case-fatality ( <1-9%) varied significantly by region, with higher rates in Africa and South America.
Conclusions:
- The review provides essential data for establishing intussusception surveillance systems.
- Findings support the ongoing monitoring of rotavirus vaccine safety worldwide.
- Understanding regional variations in intussusception is crucial for effective vaccine program safety oversight.
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