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Updated: May 9, 2026

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
Published on: November 24, 2014
Current interventional coronary applications of excimer laser.
Francesco Fracassi1, Marco Roberto, Giampaolo Niccoli
1Institute of Cardiology, Catholic University of the Sacred Heart, Largo Agostino Gemelli 8, 00168 Rome, Italy.
Excimer laser angioplasty effectively removes thrombus and debulks plaque, improving stent placement in percutaneous coronary intervention. Further randomized trials are needed to confirm its role in various coronary lesion types.
Area of Science:
- Cardiovascular Interventions
- Medical Device Technology
- Laser Applications in Medicine
Background:
- Percutaneous coronary intervention (PCI) techniques are evolving.
- Excimer laser technology has advanced, improving safety and efficacy.
- Increased use of excimer laser as an adjunctive PCI device.
Purpose of the Study:
- To review the current applications and benefits of excimer laser angioplasty.
- To highlight its efficacy in specific lesion types, including thrombus-containing lesions.
- To identify areas for future research and clinical validation.
Main Methods:
- Review of current literature and clinical data on excimer laser use in PCI.
- Analysis of technical advancements and their impact on outcomes.
- Summary of established and emerging indications for laser angioplasty.
Main Results:
- Excimer laser facilitates rapid thrombus removal and plaque debulking.
- It improves stent deployment and reduces microvascular obstruction.
- Effective for in-stent restenosis, chronic total occlusions, and vein graft lesions.
Conclusions:
- Excimer laser angioplasty shows promise as an adjunctive PCI tool.
- It offers benefits in thrombus removal, plaque modification, and specific lesion subsets.
- Randomized controlled trials are necessary to define its definitive role compared to standard therapies.
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