Related Experiment Video
Updated: May 9, 2026
Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
Published on: August 16, 2019
Treatment for depression following mild traumatic brain injury in adults: a meta-analysis
Suzanne Barker-Collo1, Nicola Starkey, Alice Theadom
1Department of Psychology, Faculty of Sciences, University of Auckland, Auckland, New Zealand. s.barker-collo@auckland.ac.nz
Primary Objective:
Development of depression after TBI is linked to poorer outcomes. The aim of this manuscript is to review evidence for the effectiveness of current treatments.
Research Design:
Two meta-analyses were undertaken to examine the effectiveness of both pharmacological and non-pharmacological interventions for depression after mild TBI.
Method And Procedures:
PubMed, Medline, PsychInfo, Web of Science and Digital Dissertations were searched and 13 studies located. Meta Analyst Beta 3.13 was used to conduct analyses of pre- vs post-effects then to examine treatment group vs control group effects.
Main Outcomes And Results:
Studies using a pre-post design produced an overall effect size of 1.89 (95% CI = 1.20-2.58, p < 0.001), suggesting that treatments were effective; however, the overall effect for controlled trials was 0.46 (95% CI = -0.44-1.36, p < 0.001), which favoured the control rather than treatment groups.
Conclusions:
This study highlights the need for additional large well-controlled trials of effective treatments for depression post-TBI.
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