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Related Experiment Videos

Anaphylatoxin and terminal complement complexes in red cell salvage.

A Bengtsson1, B Lisander

  • 1Department of Anesthesiology and Intensive Care, Sahlgrens Hospital, Göteborg, Sweden.

Acta Anaesthesiologica Scandinavica
|July 1, 1990
PubMed
Summary

This study found that while red cell salvage equipment activates the complement system, the washing process removes most anaphylatoxins and terminal complement complexes. Autotransfusion did not cause systemic complement activation in patients undergoing surgery.

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Area of Science:

  • Immunology
  • Transfusion Medicine
  • Surgical Research

Background:

  • Red cell salvage is used in surgery to reinfuse a patient's own blood.
  • The complement system, including anaphylatoxins (C3a, C5a) and terminal complement complex (TCC), can be activated during blood processing.
  • Potential systemic complement activation following autotransfusion is a concern.

Purpose of the Study:

  • To investigate the formation of anaphylatoxins (C3a, C5a) and TCC during red cell salvage.
  • To assess for systemic complement activation after autotransfusion in patients undergoing elective orthopedic surgery.

Main Methods:

  • Studied 13 patients undergoing elective orthopedic surgery.
  • Analyzed C3a, C5a, and TCC levels in the salvaged erythrocyte fraction.

Related Experiment Videos

  • Measured plasma levels of C3a, C5a, and TCC before and after autotransfusion.

    • Main Results:

    • Elevated C3a levels were detected in the washed erythrocyte suspension.
    • C5a and TCC concentrations were not increased in the suspension.
    • No significant systemic complement activation was observed in patients post-autotransfusion.

    Conclusions:

    • The cell-saver equipment activates the complement system.
    • The washing procedure effectively removes most anaphylatoxins and TCC from the salvaged red cells.
    • Autotransfusion following red cell salvage does not appear to cause extensive systemic complement activation in this patient group.