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Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
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Updated: May 9, 2026

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
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Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

Imaging in systemic amyloidosis.

Sajitha Sachchithanantham1, Ashutosh D Wechalekar

  • 1Center for Amyloidosis and Acute Phase Proteins, University College London Medical School, London, UK.

British Medical Bulletin
|July 31, 2013
PubMed
Summary
This summary is machine-generated.

Non-invasive imaging aids systemic amyloidosis diagnosis and monitoring. While ¹²³I-SAP scintigraphy assesses visceral amyloid, cardiac imaging like echocardiography, MRI, and nuclear tracers are crucial for cardiac involvement, with PET showing future promise.

Keywords:
CMRDPDPETSAPimagingsystemic amyloidosis

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Area of Science:

  • Diagnostic imaging
  • Nuclear medicine
  • Cardiology

Background:

  • Systemic amyloidosis diagnosis is challenging.
  • Histology offers limited insight into disease extent and monitoring.
  • Non-invasive imaging can evaluate amyloid burden, organ involvement, and treatment response.

Purpose of the Study:

  • To review current non-invasive imaging modalities for systemic amyloidosis.
  • To highlight the utility and limitations of various imaging techniques.
  • To identify areas for future research in amyloid imaging.

Main Methods:

  • Literature search of PubMed using keywords: 'amyloid imaging', 'SAP scintigraphy', 'cardiac MRI', 'PET and amyloidosis', 'nuclear imaging'.
  • Review of studies on diagnostic imaging in systemic amyloidosis.

Main Results:

  • ¹²³I-SAP scintigraphy is the primary tool for assessing visceral amyloid deposition.
  • Echocardiography is key for cardiac amyloidosis; cardiac MRI is increasingly valuable.
  • Bone-seeking tracers (99mTc-DPD) show promise for transthyretin cardiac amyloidosis.

Conclusions:

  • No single imaging modality is sufficient for all amyloidosis types and organs.
  • 99mTc-DPD shows potential for early diagnosis of cardiac transthyretin amyloidosis.
  • Further research is needed for ¹²³I-mIBG and PET tracers in systemic amyloid imaging.