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A disulphide bond in the E2 enzyme Pex4p modulates ubiquitin-conjugating activity

Chris Williams1, Marlene van den Berg, Will A Stanley

  • 1European Molecular Biology Laboratory, Structural Biology Unit, Notkestrasse 85, 22603, Hamburg, Germany.

Scientific Reports
|July 31, 2013
PubMed
Summary

The Pex4p enzyme forms a unique disulfide bond, crucial for its activity in ubiquitination. Mutating this bond reduces enzyme function by altering the active site, impacting Pex5p receptor regulation.

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